Abstract
The effect of the extract (100 mg/kg and 1 g/kg) and the tincture (1 and 5 ml/kg) of the goutweed ( Aegopodium podagraria L. ) aerial part on the physical endurance, the level of depression and cognitive functions has been studied using the weight-loaded forced swimming test, the extrapolation escape test, and the reserpine-induced depression model. The goutweed extract in the dose of 100 mg/kg, but not in the dose of 1 g/kg, significantly increases the exhaustive swimming time (10% and 20% load) in male mice. In female mice the augmentation of exhaustive swimming time is registered with 20% load against the background of the extract in both doses. The goutweed tincture does not change the results of this test. Goutweed medicines have the ambiguous effect on the results of the extrapolation escape test: the extract and the tincture do not change the percentage of mice that succeed in completing the task, still the average time spent for the task performance is significantly decreased in these animals (but not within the whole group) against the background of the extract in the doses of 100 mg/kg and 1 g/kg. The extract in the dose of 100 mg/kg significantly reduces the number of rats capable of completing the task, the extract (1 g/kg) and the tincture (1 ml/kg) increase the time spent for performing the extrapolation escape task by rats. The extract and the tincture do not change the body temperature reduction and blepharoptosis induced by reserpine in rats. Thus, the goutweed extract is able to increase the physical endurance, exert a moderate positive effect on cognitive functions in mice (but not in rats) without any significant changes in the level of depression. The goutweed tincture worsens the results of the extrapolation escape test in the dose of 1 ml/kg, does not change them in the dose of 5 ml/kg and does not influence on the level of depression and physical endurance in both doses.
Highlights
The effect of the extract (100 mg/kg and 1 g/kg) and the tincture (1 and 5 ml/kg) of the goutweed (Aegopodium podagraria L.) aerial part on the physical endurance, the level of depression and cognitive functions has been studied using the weight-loaded forced swimming test, the extrapolation escape test, and the reserpine-induced depression model
In female mice receiving the GW extract in both doses the effect was manifested only when 20% load was used (Fig. 3, Fig. 4, with 10% load only drastic augmentation of physical performance in certain animals was seen after administration of the extract in the lower dose and the tincture in the high dose)
The mechanism of action of the extract can be associated with favourable peripheral metabolic effects, as well as with the psychotropic activity of this medicine
Summary
The effect of the extract (100 mg/kg and 1 g/kg) and the tincture (1 and 5 ml/kg) of the goutweed (Aegopodium podagraria L.) aerial part on the physical endurance, the level of depression and cognitive functions has been studied using the weight-loaded forced swimming test, the extrapolation escape test, and the reserpine-induced depression model. Goutweed medicines have the ambiguous effect on the results of the extrapolation escape test: the extract and the tincture do not change the percentage of mice that succeed in completing the task, still the average time spent for the task performance is significantly decreased in these animals (but not within the whole group) against the background of the extract in the doses of 100 mg/kg and 1 g/kg. The aim of this study was to evaluate the efficacy of medicines with A. podagraria L. in the weight-loaded forced swimming test, the extrapolation escape test, as well as reserpine-induced depression
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