Abstract
Six 3-year-old goats (three males and three females) weighing 60.0 ± 18 kg (mean ± SD) were used to investigate the effect of medetomidine (MED; 20 μg kg−1 IV) and its antagonism with atipamezole (ATI; 100 μg kg−1 IV) on physiologic responses (heart rate (HR; beats minute−1), respiratory rate (RR; breaths minute−1), electrocardiogram (ECG), rectal temperature (T; °C), blood pressure (oscillometric; mm Hg), sedation (SED), posture (REC), analgesia (ALG), and stress-related hormonal and metabolic responses (epinephrine and norepinephrine (high performance liquid chromatography with electrochemical detection), cortisol (COR; μg dL−1; radioimmunoassay), glucose (GLU; mg mL−1; enzymatic colorimetric assay), and free fatty acids (modified enzymatic colorimetric assay)); each goat received ATI or SAL in random order separated by 1 week.
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