Application effect of procedural sedation and analgesia solution that aiming at shallow sedation in critical patients with mechanical ventilation

Abstract

Objective To observe the application effect of procedural sedation and analgesia solution that aiming at shallow sedation in critical patients with mechanical ventilation. Methods Totally 160 patients with mechanical ventilation who accepted endotracheal intubation and without cerebral organic lesions in intensive care unit (ICU) of our hospital from February 2014 to February 2015 were assigned to the observation group and the control group at random. Patients in the control group received drug sedation and analgesia treatment and the dosage was regulated according to the medication orders; patients in the observation group received the procedural sedation and analgesia solution that aiming at shallow sedation. Doctors made plans and aim of sedation and analgesia, and nurses dynamically evaluated the standard situation of sedation and analgesia and regulated the dosage according to the assessment results. We compared the dosage of sedation drugs, the time of mechanical ventilation, ICU time and the incidence of delirium between two groups. Results The dosage of sedation drugs in the observation group were: disoprofol, (5 690±618.610) mg; dexmedetomidine, (1 642.5±317.330) μg; the mechanical ventilation time was (4.77±0.740) d, and the ICU time was (5.78±0.750) d. Those data were all lower than the control group (t=9.587, 9.523, 6.291, 6.260; P<0.05). The incidence of delirium was 13.75% in the observation group, and was 26.25% in the control group (χ2=3.91, P<0.05). Conclusions The procedural sedation and analgesia solution that aiming at shallow sedation could effectively reduce the dosage of sedation drugs, shorten the mechanical ventilation time, reduce the incidence of delirium and is worth to popularization and application. Key words: Respiration, artificial; Critical patients; Procedural sedation and analgesia