Abstract
In order to explain a risk factor for osteoporosis, effects of chronic malabsorption on bone mass were experimentally assessed. In beagles, the distal three quarters of the small intestine was resected, and effects of the deficit on bone mass was studied. After double tetracycline labelling each dog was sacrificed, and sections of undecalcified lumbar vertebra were prepared for bone morphometry. Effects of postoperative treatment with ursodesoxycholic acid(UDCA) and 1α(OH)D3 or with 1α(OH)D3 alone were also evaluated.
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