Abstract
The effect of low- and high-humidity ageing on hardness, disintegration time and dissolution rate of dibasic calcium phosphate dihydrate-based tablets prepared at different initial moisture concentrations was studied. Hardness increased while distintegration and dissolution rate decreased on ageing in low humidity. The dissolution rate of tablets containing higher initial moisture was slower than the tablets containing lower initial moisture. On ageing in high humidity, hardness, disintegration and dissolution rates decreased at all initial moistures. The results suggest that the effects of moisture and humidity should be thoroughly investigated for dibasic calcium phosphate dihydrate-based tablets in order to ensure stability and bioavailability of the drug.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
