Abstract
BackgroundTo compare the effect of loteprednol suspension eye drops after corneal transplantation with the effect of prednisolone acetate eye drops.MethodsA total of 234 patients (234 eyes) who underwent penetrating keratoplasty (PKP) and lamellar keratoplasty (LKP) were retrospectively included. Patients who received 1 % prednisolone acetate eye drops were defined as 1 % prednisolone acetate eye drop group (n = 96), and patients who received 0.5 % loteprednol suspension eye drops were defined as 0.5 % loteprednol suspension eye drop group (n = 138).Results35 cases in 1 % prednisolone acetate eye drops group and 27 cases in 0.5 % loteprednol suspension eye drops group developed corticosteroid-induced ocular hypertension, and were defined as prednisolone acetate group and loteprednol group. No significant differences were observed in the average intraocular pressure (IOP) at 1 week, 1 month, 3 months or 12 months postoperatively. There were significant differences in the average IOP between the two groups at 6 months postoperatively (P = 0.001). There were no significant differences in the average best corrected visual acuity (BCVA) at 1, 3 and 12 months postoperatively between two groups. The average 6-month postoperative BCVA was significantly higher in the prednisolone acetate group than the loteprednol group (P < 0.05). There were no significant differences in the postoperative graft rejection rates between the two groups (P > 0.05).Conclusions0.5 % loteprednol suspension eye drops may be considered for long-term use after corneal transplantation.
Highlights
To compare the effect of loteprednol suspension eye drops after corneal transplantation with the effect of prednisolone acetate eye drops
The prevention of graft rejection requires long-term use of local corticosteroids, which significantly increases the incidence of corticosteroidinduced ocular hypertension [3]. 1 % prednisolone acetate eye drops are the first choice to prevent corneal transplant rejection, but their long-term use can lead to the occurrence of steroid-induced glaucoma [4]
The inclusion criteria were patients who (1) were aged ≥ 18 years; (2) underwent penetrating keratoplasty (PKP) and lamellar keratoplasty (LKP); (3) received 1 % prednisolone acetate eye drops after the operation; (4) used tacrolimus eye drops or cyclosporine eye drops for anti-rejection treatment; and (5) had early intraocular pressure (IOP) ≤ 21 mmHg after the operation
Summary
To compare the effect of loteprednol suspension eye drops after corneal transplantation with the effect of prednisolone acetate eye drops. The prevention of graft rejection requires long-term use of local corticosteroids, which significantly increases the incidence of corticosteroidinduced ocular hypertension [3]. 1 % prednisolone acetate eye drops are the first choice to prevent corneal transplant rejection, but their long-term use can lead to the occurrence of steroid-induced glaucoma [4]. Loteprednol suspension eye drops can penetrate the cornea and travel to the intraocular tissues more efficiently than prednisolone acetate eye drops since they possess esters instead of ketones at the C20 position, which is highly. Loteprednol suspension eye drops are used in the treatment of cataracts [6], corneal refractive surgery [7, 8] inflammation after corneal transplantation [4], vernal keratoconjunctivitis [9], blepharoconjunctivitis [10] and uveitis [11]
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