The effect of local anesthetics on calcium transport across the rat and turtle small intestine

Abstract

1. 1. Procaine at different concentrations enhanced significantly ( P < 0.01) calcium accumulation in rat intestinal cells, whereas the same concentrations of procaine inhibited significantly ( P < 0.01) calcium uptake by the turtle small intestine. 2. 2. Unidirectional calcium influx across the rat small intestine was significantly enhanced ( P < 0.001) by the presence of procaine in the preincubation medium. However, procaine had no effect on calcium influx across the turtle intestinal cells. 3. 3. The cell water content and the cell volume were not altered by preincubating the intestinal tissues with procaine in both animals.