Abstract
The Effect of Lipoid Solvents on the Rate of Elimination and the Carcinogenic Potency of 3:4-Benzpyrene after Subcutaneous Injection in Mice
Highlights
Oxidation of 3:4-Benzpyrene in vitro. It has been suggested (Weil-Malherbe and Dickens, 1946) that the retardation of benzpyrene elimination and the delay of tumour formation caused by phospholipids might be cortnected with their antioxidant properties
It was realized from the beginning that antioxidant activity in the accepted sense cannot be expected to occur in the living animal cell
An effect in the opposite direction was found when the oxidation of benzpyrene was carried out in a lipoid medium. In these experiments a solution of perbenzoic acid in tricaprylin was added to a tricaprylin solution of benzpyrene (Table II)
Summary
Phospholipids.-Phospholipids were prepared from ox brain by the method previously described (Weil-Malherbe and Dickens, 1946), with the difference that the preparation was done on a larger scale, 2300 g. of brain being used as starting material. It has been suggested (Weil-Malherbe and Dickens, 1946) that the retardation of benzpyrene elimination and the delay of tumour formation caused by phospholipids might be cortnected with their antioxidant properties It was, realized from the beginning that antioxidant activity in the accepted sense cannot be expected to occur in the living animal cell. Carcinogenic hydrocarbons, such as 20-methylcholanthrene (Simpson and Cramer, 1945) or 3:4-benzpyrene (Weigert and Mottram, 1946) seem to be oxidized as soon as they permeate into the interior of almost any living cells with which they come into contact Their oxidation is more likely to be incidental to the normal metabolic aetivities of the cell than to the action of a specific enzyme. After addition of 0-2 ml. 30 per cent hydrogen peroxide the tubes were left at room temperature for 16 hours
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