Abstract
The analgesic activity of diphenylpropylamines are expressed in quantitative symbols, equiactive dose, ED 50 -doses, threshold doses, or potency ratios. The usual standards of reference are morphine, methadone, and pethidine. This chapter discusses the quantitative results obtained in 50 experimental conditions with these compounds and with codeine by 28 authors. Nearly all authors found methadone more active than morphine, morphine more active than pethidine, and pethidine more active than codeine by subcutaneous injection in both rats and mice. The chapter also presents the analgesic potency ratios of methadone, morphine, pethidine, and codeine as determined by subcutaneous injection in mice and rats in 46 different experimental conditions. The results show that there is no detectable correlation between equiactive dose level and potency ratio. The potency ratios and equiactive dose levels determined after intraperitoneal injection injection are not significantly different from those obtained after subcutaneous injection.
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