The effect of leiomyomas smaller than 5cm in diameter on the ICSI outcome

Abstract

ObjectiveTo evaluate the effects of intramural and subserosal uterine leiomyomas with a smaller than 5cm diameter on the outcome of IVF.DesignA retrospective, case-controlled study was conducted in a referral center for assisted reproduction.Materials and methodsOne hundred and fifty-two patients with subserosal and/or intramural myomas constituted the study group and 160 patients with tubal factor infertility without myoma in the uterus formed the control group. The two groups were compared with respect to implantation rate, clinical pregnancy rate. Logistic regression analysis was performed to identify the possible predictors of clinical pregnancy rate.ResultsThe clinical pregnancy rate of the control group was higher than the leiomyoma group (26.9% vs. 11.8%, P=0.001). The implantation rate of the study and the control groups was statistically significant (27/327;8.25% vs. 66/409;16% respectively P=0.001). The mean age of the leiomyoma group was significantly older than the control group (P<0.001). The mean number of oocytes retrieved and the number of good quality embriyos transferred were significantly lower in the leiomyoma group compared to the control group (P<0.05). In the multivariate analysis, total basal antral follicle count (OR = 1.12, 95% CI = 1.03–1.22, P=0.008) and the number of good quality embriyos transferred (OR = 2.2, 95% CI = 1.47–3.41, P<0.001) were the most important predictors of the clinical pregnancy.ConclusionsIntramural and subserozal myomas under 5 cm diameter have no effect on clinical pregnancy rate at ICSI cycle. ObjectiveTo evaluate the effects of intramural and subserosal uterine leiomyomas with a smaller than 5cm diameter on the outcome of IVF. To evaluate the effects of intramural and subserosal uterine leiomyomas with a smaller than 5cm diameter on the outcome of IVF. DesignA retrospective, case-controlled study was conducted in a referral center for assisted reproduction. A retrospective, case-controlled study was conducted in a referral center for assisted reproduction. Materials and methodsOne hundred and fifty-two patients with subserosal and/or intramural myomas constituted the study group and 160 patients with tubal factor infertility without myoma in the uterus formed the control group. The two groups were compared with respect to implantation rate, clinical pregnancy rate. Logistic regression analysis was performed to identify the possible predictors of clinical pregnancy rate. One hundred and fifty-two patients with subserosal and/or intramural myomas constituted the study group and 160 patients with tubal factor infertility without myoma in the uterus formed the control group. The two groups were compared with respect to implantation rate, clinical pregnancy rate. Logistic regression analysis was performed to identify the possible predictors of clinical pregnancy rate. ResultsThe clinical pregnancy rate of the control group was higher than the leiomyoma group (26.9% vs. 11.8%, P=0.001). The implantation rate of the study and the control groups was statistically significant (27/327;8.25% vs. 66/409;16% respectively P=0.001). The mean age of the leiomyoma group was significantly older than the control group (P<0.001). The mean number of oocytes retrieved and the number of good quality embriyos transferred were significantly lower in the leiomyoma group compared to the control group (P<0.05). In the multivariate analysis, total basal antral follicle count (OR = 1.12, 95% CI = 1.03–1.22, P=0.008) and the number of good quality embriyos transferred (OR = 2.2, 95% CI = 1.47–3.41, P<0.001) were the most important predictors of the clinical pregnancy. The clinical pregnancy rate of the control group was higher than the leiomyoma group (26.9% vs. 11.8%, P=0.001). The implantation rate of the study and the control groups was statistically significant (27/327;8.25% vs. 66/409;16% respectively P=0.001). The mean age of the leiomyoma group was significantly older than the control group (P<0.001). The mean number of oocytes retrieved and the number of good quality embriyos transferred were significantly lower in the leiomyoma group compared to the control group (P<0.05). In the multivariate analysis, total basal antral follicle count (OR = 1.12, 95% CI = 1.03–1.22, P=0.008) and the number of good quality embriyos transferred (OR = 2.2, 95% CI = 1.47–3.41, P<0.001) were the most important predictors of the clinical pregnancy. ConclusionsIntramural and subserozal myomas under 5 cm diameter have no effect on clinical pregnancy rate at ICSI cycle. Intramural and subserozal myomas under 5 cm diameter have no effect on clinical pregnancy rate at ICSI cycle.