Abstract
This study dealt with the effect of Lactobacillus acidophilus concentrated filtrate on polychromatic erythrocyte. The result showed that Lactobacillus acidophilus concentrated filtrate caused a non significant decrease in micronucleus formation at first dose in comparison with negative control while a significant decrease in micronucleus formation was shown in albino male mice at second and third doses in comparison with negative and positive controls. The result of post-treatment by concentrated filtrate also caused a significant decrease in micronucleus formation while the pre-treatment caused non significant decrease in the micronucleus formation in comparison with the corresponding control.
Highlights
Cytogenetic analyses have been employed widely to detect the effect of mutagens and carcinogens on the genetic make-up
Schroder [6, 7] recommended the use of bone marrow smears to detect in vivo genetic damage induced by chemical mutagens and demonstrated the occurrence of micronuclei in bone marrow cells in connection with cytogenetic damages
Group II: The animals were treated with cyclophosphomide at a dose of 15 mg/kg Group III: The animals were treated with three doses of the Lactobacillus acidophilus concentrated (250, 500 and 750 mg/kg) (24 animals)
Summary
Cytogenetic analyses have been employed widely to detect the effect of mutagens and carcinogens on the genetic make-up. In pre-treatment interaction, the Lactobacillus acidophilus concentrated filtrate was given for 6 days (single dose/day), while cyclophosphomide was given in day 7, and animals were sacrificed in day 8 for laboratory assessments. In both cases, the materials were given orally (0.1 ml). In post-treatment interaction, the animals was given cyclophosphomide on the first day, while the Lactobacillus acidophilus concentrated filtrate was given in the 2nd day till day 7 (single dose/day), and animals were sacrificed in day 8 for laboratory assessments The selection of ideal dose was based on the results of micronucleus formation as indicated in table (1) in which no significant differences was observed between the concentrated filterate treated mice and negative control
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