The effect of ketotifen combined with ambroxol hydrochloride atomization treatment on respiratory function index of children with bronchitis

Abstract

Objective To explore the effect of ketotifen combined with ambroxol hydrochloride atomization treatment on respiratory function index of children with bronchitis. Methods 58 children with bronchitis in our hospital from October 2014 to October 2016 were selected as clinical research object, and divided into test group and control group according to the random number table method, 29 cases in each group. All children were given conventional treatment, on the basis the children of control group were given oral ketotifen, the children of test group were given ketotifen combined with ambroxol hydrochloride atomization treatment. Compared respiratory function, clinical symptoms before and after treatment, and adverse drug reactions of two groups. Results The levels of tidal volume, respiratory rate (RR), tPTEF/tE, and VPTEF/VE improved markedly in the two groups after treatment, the levels of tidal volume, tPTEF/tE, and VPTEF/VE of the test group were significantly higher than those of the control group [(7.54±1.24)ml/kg vs.(6.31±1.21)ml/kg, (28.68±4.51)% vs.(24.12±3.72)%, (30.42±5.31)% vs.(25.64±3.75)%; P<0.05], RR was significantly lower than that of the control group [(30.11±5.23) times/min vs.(37.44±5.15) times/min; P<0.05]. The clinical symptoms disappear time (cough, shortness of breath, wet rale, and wheeze) and the recovery time of heart rate and body temperature of the test group were significantly shorter than those of the control group [(5.13±1.10)d vs.(6.76±1.53)d, (4.12±0.74)d vs.(6.45±1.33)d, (5.20±1.04)d vs.(7.32±1.41)d, (3.24±0.47)d vs.(5.11±0.84)d, (2.14±0.64)d vs.(3.52±1.10)d, (2.43±0.53)d vs.(4.85±0.66)d; P<0.05]. The incidence of adverse drug reactions (rash, urticaria, throat stimulation and discomfort, hoarseness, and cough) of the test group was significantly lower than that of the control group (13.79% vs.37.93%; P<0.05). Conclusion Ketotifen combined with ambroxol hydrochloride atomization treatment can obviously improve the clinical symptoms of children with bronchitis, shorten the treatment time, promote the recovery of respiratory function, with distinct curative effect and high safety. Key words: Ketotifen; Ambroxol hydrochloride; Aerosol inhalation; Infantile bronchitis; Respiratory function