Abstract

The effect of iontophoretically applied kainic acid on the response of CA1 neurones to Schaffer collateral stimulation has been studied in rat hippocampal slices. Brief applications of kainate to the cell body region of the slice resulted in a large and long lasting potentiation of the population spike evoked by Schaffer collateral stimulation. This effect was not mimicked by l-glutamate, l-aspartate, acetylcholine or GABA, and may be associated with the neurotoxic action of kainic acid.

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