The Effect Of Iomeprol On Platelet Aggregation And Potential Risk Of Thrombogenecity

Abstract

Iomeprol is a newer triiodinated nonionic low osmolar monomeric radiographic contrast agent. The physicochemical characteristics of this compound show high water solubility (aqueous solutions of higher iodine concentrations) which allows the formulation of contrast media to have lower osmolalities and viscosities. Lower viscosity values make this contrast agent flow better through catheters, allowing easier manual injection. Its formulation contains 400 mg iodine/ml, the highest concentration so far available on the market for non-ionic contrast media, resulting in better X-ray attenuation and image quality. Although Iomeprol appears to have a favorable profile because of the absence of EDTA (ethylene diamine tetra acetic acid) and the presence of trometamol, hydrochloric acid, water as buffer and stabilizer in its structure, it is still unknown whether this has a distinct advantage on thrombogenicity. In this article, we investigated the potential thrombogenicity of Iomeprol, a non-ionic, low osmolar radiocontrast medium, by measuring its effect on platelet reactivity and noted similarities with other non-ionic low osmolar agents. With the use of ADP, AYPGKF, and collagen stimulation, this contrast agent inhibited platelet aggregation at 50% contrast concentration, whereas the contrast medium did not inhibit aggregation at 10% concentrations. This behavior was similar to other non-ionic agents in its class in terms of platelet reactivity despite its unique properties.