Abstract
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Highlights
To evaluate the influence of cholinergic stimulation on the composition of glycoconjugates in goblet cells, we studied the tracheal epithelium of rabbits 5 minutes and 20 minutes after i.v. administration of acetylcholine in doses 0.1 mg and 0.5 mg, respectively
We demonstrated that the goblet cells (GC) in the rabbit tracheal epithelium were overstimulated and damaged due to the intravenous (i.v.) administration of acetylcholine
To complete our previous studies, we decided to study the effect of i.v. administered acetylcholine on the composition of the mucus secreted by GC in the tracheal epithelium of rabbits
Summary
To evaluate the influence of cholinergic stimulation on the composition of glycoconjugates in goblet cells, we studied the tracheal epithelium of rabbits 5 minutes and 20 minutes after i.v. administration of acetylcholine in doses 0.1 mg and 0.5 mg, respectively. Using both conventional and lectin histochemistry, we compared the percentage of tracheal goblet cells containing neutral glycoconjugates to those containing total acidic glycoconjugates, sulphated acidic glycoconjugates, and sialylated acidic glycoconjugates. The higher dose evoked a decrease in percentage of both neutral- and sialylated glycoconjugates-containing goblet cells. To complete our previous studies, we decided to study the effect of i.v. administered acetylcholine on the composition of the mucus secreted by GC in the tracheal epithelium of rabbits
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