Abstract
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Highlights
Previous studies on the effect of various mucolytic drugs on the tracheal epithelium ultrastructure revealed ambroxol as the most harmful one
Twenty minutes after oral administration of 7.5 mg of ambroxol, goblet cells containing neutral glycoconjugates disappeared from the rabbit tracheal epithelium
The equivalency of sialylated glycoconjugate-detecting methods was tested by the paired t-test, median test, and Wilcoxon’s paired test. The tracheae of both control and treated rabbits were lined with the pseudostratified columnar ciliated epithelium composed mostly of ciliated, goblet, and basal cells
Summary
Previous studies on the effect of various mucolytic drugs on the tracheal epithelium ultrastructure revealed ambroxol as the most harmful one. Oral administration of ambroxol only slightly affected the composition of glycoconjugates contained in goblet cells of the tracheal epithelium in rabbits. The most frequently used mucolytic agent in clinical practice, affects both ciliated and secretory cells in the respiratory system It stimulates ciliary activity as well as incorporation of precursors into phospholipids in granular pneumocytes causing a decrement of mucus adhesion to the hypophase. It facilitates incorporation of hydrolytic enzymes into lysosomes of the airways’ secretory cells Activation of these acidic mucopolysaccharide-degrading enzymes leads to a decrease of the sputum viscosity (·míd and Holcát 1994). Lamb and Reid (1972) and Damyanov (1987) deduced a common tendency to the decrease of sialylated glycoconjugates and the increase of sulphated ones as the reaction to any alteration of the tracheal epithelium
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