Abstract
The aim of this study was to show the effect of intratracheal (IT) and intravenous (IV) lidocaine on haemodynamic and arterial blood gas values in hydrochloric acid (HCl) induced-acute lung injury (ALI) in rabbits. Twenty New Zealand rabbits were randomly divided into for groups of five. An endotracheal tube was placed through a tracheostomy in all animals following ketamine hydrochloride (50 mg/kg, intramuscularly) induced anaesthesia. Maintenance of anaesthesia was achieved by the use of ketamine hydrochloride 10 mg/kg/h and atracurium besylate 1 mg/kg/h. The animals were ventilated with Pressure Control mod for 3 hours and the parameters of ventilation were FiO2: 1.0, RR: 80/min, Vt: 8 ml/kg, I/E: 1/2, PEEP: 5 cmH2O. Intratracheal HCl (2 ml/kg), was given following tracheostomy in all animals. Five minutes after the application of HCl the group 1 received IV lidocaine (2 mg/kg), group 2 received IT lidocaine (2 mg/kg), group 3 received IV lidocaine (4 mg/kg) and group 4 received IT lido-caine (4 mg/kg). We recorded mean arterial blood pressures (MAP), heart rate (HR) every 60 min. We measured arterial blood gas values (PaO2, PaCO2, pH) at beginning of the study, at 90th and 180th minutes. Data were compared by Mann–Whitney U-test. A P value of less than 0.05 was considered to indicate statistical significance. MAP levels of group 2 and group 4 were higher than group 1 and group 3 at 120th and 180th minutes (P < 0.05). HR levels of group 2 were lower than the other groups at 120th and 180th minutes (P < 0.05). PaO2 levels of group 1 were higher than the other groups at 180th minute (P < 0.001). There was no significant difference between four groups regarding PaCO2, pH. In conclusion, IT and IV lidocaine (2 mg/kg) given after 5 min of HCl application had a beneficial effect on the haemodynamic and arterial blood gas values in acute lung injury in rabbits model.
Highlights
In our experience, very often, even with a nonrebreathing mask (NRM), high oxygen delivery to patient with the existent materials is insufficient
TMSORG for R, C, N and Re were significantly associated with HM
P109 How we reduce allogenic blood transfusions in the patients undergoing surgery of ascending aorta D Radojevic, Z Jankovic, B Calija, M Jovic, B Djukanovic
Summary
Very often, even with a nonrebreathing mask (NRM), high oxygen delivery to patient with the existent materials is insufficient. There is evidence that increasing the dose of continuous renal replacement therapy (CRRT) is associated with improved survival in critically ill patients with acute renal failure (ARF) [1]. The aim of this study is to investigate if there is any difference in patients’ characteristics in ICU between COPD and nonCOPD diseases caused chronic respiratory failure and require mechanical ventilation during acute exacerbations. Noninvasive positive pressure ventilation (NPPV) has been reported to be beneficial in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD), and to facilitate weaning In this trial we assessed the possible benefit of early NPPV in patients with blunt chest trauma and acute respiratory failure. The aim of this study was to compare the pharmacokinetic and pharmacodynamic parameters and the clinical efficacy of a continuous infusion of cefepime versus an intermittent regimen in critically ill adults patients with gram negative bacilli infection. The purpose of the study is to identify the factors associated with DNR status in our institution
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
