Abstract
This study investigated the influence of simulated gastrointestinal digestion on phenolic bioaccessibility, antioxidant activity, and enzyme inhibition of Prinsepia utilis Royle fruits. Gastric and intestinal digestion remarkably upgraded the total phenolic and flavonoid contents, whereas the total anthocyanin content increased after gastric digestion but declined after intestinal digestion. Nineteen phenolics were characterized in P. utilis fruits among which rutin had the highest content in undigested and intestinally digested samples. Cyanidin-3-O-glucoside had the highest content in the gastrically digested sample. After digestion, fruit antioxidant activity and inhibitory effects on α-glucosidase and pancreatic lipase were enhanced significantly (p < 0.05), whereas the inhibitory effects on dipeptidyl peptidase IV (DPP-IV) declined dramatically (p < 0.05). Correlation analysis indicated that protocatechuic acid and p-coumaric acid may be the most effective compounds in antioxidant and inhibition towards pancreatic lipase and α-glucosidase, while quercetin-3-O-glucoside and quercetin-3- (6-O-acetyl-beta-glucoside) may contribute significantly on DPP-IV inhibition. The results of this study may help further elucidate the phenolic digestive stability of P. utilis fruits and their effects on human health, and provide information for the further utilization of this fruits.
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