Abstract
Background/aimThis study was conducted to determine the critical partial oxygen pressure (pO2) value that would impair hearing function by evaluating the effects of hypoxia on hearing function in subjects diagnosed with chronic obstructive pulmonary disease (CPOD).Materials and methodsThe study included 25 male and 5 female patients referred to our clinic who were diagnosed with COPD, according to spirometry and PaO2 values, and who did not show pathology upon autoscopic examination. The control group consisted of 14 female and 16 male patients who had no lung disease and were in the same age range as the COPD group.ResultsA statistically significant difference was found between the two groups for distortion-product otoacoustic emission (DPOAE) (P < 0.001). The COPD group was divided into two groups according to pO2 levels (pO2 ≤ 70 and pO2 > 70) in order to find a critical pO2 level which might cause significant change at a certain audiological extent.ConclusionHypoxia causes long-term decline in hearing thresholds, deterioration of DPOAE results, and prolongation of I–V interpeak latency in auditory brainstem response. However, the critical oxygen level that disrupts hearing function could not be determined.
Highlights
Chronic obstructive pulmonary disease (COPD) is a progressive and irreversible systemic lung disease that restricts airflow [1]
A statistically significant difference was found between the two groups for distortion-product otoacoustic emission (DPOAE) (P < 0.001)
The COPD group was divided into two groups according to pO2 levels in order to find a critical pO2 level which might cause significant change at a certain audiological extent
Summary
Chronic obstructive pulmonary disease (COPD) is a progressive and irreversible systemic lung disease that restricts airflow [1]. Irregular ventilation due to COPD results in hypoxemia, hypercapnia, and, hypoxia [2]. These functional abnormalities can be detected by arterial blood gas and pulmonary function tests [1,3]. A decrease in partial oxygen pressure (pO2) is known as hypoxemia, and in practice, it can be observed in any known pulmonary disease [1]. Hypoxia is the consequence of an inability to provide the oxygen required for cell function. Hypoxia in COPD occurs as a result of hypoxemia [4]
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