Abstract
Formaldehyde is a common agent in our surrounding environment and can adversely affect the male reproductive system. In this study, the effectiveness of Matricaria chamomilla (MC) extract as an antioxidant was investigated in rats treated with formaldehyde. Thirty-two male Wistar rats were randomly divided into six groups: F (10mg/kg formaldehyde), M200 (200mg/kg MC extract), M500 (500mg/kg MC extract), FM200 (10mg/kg formaldehyde and 200mg/kg MC extract), FM500 (10mg/kg formaldehyde and 500mg/kg MC extract) and control group (0.9% normal saline). Formaldehyde and MC extract were administered daily for 30 consecutive days via intraperitoneal injection. Hormonal status, sperm parameters, testis tissue histology, germinal cells apoptosis and stereological analyses of testis tissue were investigated. Testosterone and LH levels were significantly increased in FM200, FM500, F200 and F500 groups compared to F group (p≤0.05). Sperm count, motility and viability were significantly enhanced in FM200, FM500, F200 and F500 groups compared to F group (p≤0.05). A decrease in the number of apoptotic germ cells in FM200, FM500, M200 and M500 groups (p≤0.05) was evident. In particular, the MC extract in dose 500mg/kg is seen to reduce the adverse effects of formaldehyde on the reproductive system of male rats.
Published Version
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