Abstract
Intraperitoneal injection of Balb/c mice with Corynebacterium parvum 3 days prior to injection of sheep red blood cells produced a stimulation of direct (19S) and indirect (7S) plaque-forming cell response. Simultaneous intraperitoneal injection of C. parvum and hydrocortisone depressed the stimulatory effect of C. parvum on direct plaque cell formation in the spleen. Conversely, injection of C. parvum and hydrocortisone did not significantly affect the indirect plaque cell response. The spleen weight was increased when C. parvum was injected alone or in combination with hydrocortisone. Administration of C. parvum alone decreased the weight of the thymus. This effect was blocked when the vaccine was combined with hydrocortisone.
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