Abstract
Intraperitoneal injections of C 57 BL j 6 mice with Adriamycin or Corynebacterium parvum 3 days prior to injections of sheep red blood cells produced a stimulation of direct (19S) and indirect (7S) plaque-forming cell response. Simultaneous administration of both agents increased significantly the stimulatory effect on the plaque-forming cell response. Injections of Adriamycin did not affect the spleen weight, whereas C. parvum increased the weight of the spleen. The reducing effect of C. parvum on the thymus weight was blocked when the vaccine was administered simultaneously with Adriamycin. Adriamycin alone did not affect the weight of the thymus.
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