Abstract
Introduction: Diabetes mellitus is one of the most common metabolic diseases that causes damage to different tissues through oxidative stress. The aim of this study was to evaluate the effect of hydroalcoholic extract of Crataegus monogyna on oxidative stress, hyperglycemia and pancreatic tissue damage in diabetic rats.Methods: In this experimental study, 40 male Wistar rats were equally divided into 5 groups including control (normal saline), diabetic control (streptozotocin), intervention (streptozotocin plus C. monogyna extract at doses of 100, 200 and 400 mg/kg). After treatment, serum levels of malondialdehyde (MDA), Ferric reducing ability of plasma (FRAP) and glucose were determined. Histological sections of the pancreas were also prepared for histological examination.Results: Treatment of diabetic rats with C. monogyna extract significantly reduced blood glucose level (P < 0.05). Compared with control group MDA was increased and TCA was decreased in diabetic rats (P < 0.05). Treatment of diabetic rats with C. monogyna extract significantly increased TCA and reduced MDA (P < 0.05). In the pancreas of diabetic rats, degeneration of pancreatic acinar cells and formation of dermato space, damage of lobules and Acinii and edema were observed and treatment with C. monogyna extract ameliorated them.Conclusion: The results confirm the role of C. monogyna extract in the treatment of hyperglycemia, stress oxidative indices and pancreatic tissue damage in diabetic rats. Therefore, it might be beneficial in diabetic patients.
Highlights
Diabetes mellitus is one of the most common metabolic diseases that causes damage to different tissues through oxidative stress
The mean blood glucose levels in the STZ-receiving rats showed a significant increase compared with the control group
The serum Ferric reducing ability of plasma (FRAP) decreased significantly in the untreated diabetic rats compared to the control group rats (P < 0.001) and treatment with doses of 100, 200, and 400 mg/ kg of common hawthorn extract (P < 0.001) significantly increased the FRAP levels compared to the diabetic group (Figure 2)
Summary
Diabetes mellitus is one of the most common metabolic diseases that causes damage to different tissues through oxidative stress. The aim of this study was to evaluate the effect of hydroalcoholic extract of Crataegus monogyna on oxidative stress, hyperglycemia and pancreatic tissue damage in diabetic rats. Results: Treatment of diabetic rats with C. monogyna extract significantly reduced blood glucose level (P < 0.05). Treatment of diabetic rats with C. monogyna extract significantly increased TCA and reduced MDA (P < 0.05). Conclusion: The results confirm the role of C. monogyna extract in the treatment of hyperglycemia, stress oxidative indices and pancreatic tissue damage in diabetic rats. It might be beneficial in diabetic patients. It is estimated that more than 3.6% of the world’s population
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