The Effect of Hydro-Alcoholic Allium sativum Extract on Sexual Hormones in Mature Male Rats Under Chemotherapy With Cyclophosphamide

Abstract

Background:: Cyclophosphamide is an anticancer drug, which is used in chemotherapy. It causes alkylation of the DNA molecule. It is absorbed well by gastrointestinal tract and distributed extensively throughout the tissues and liquids of body. It also passes through the blood–brain barrier. It is turned into the active metabolites in liver and eventually excreted through the kidneys. Objectives:: In this study the effects of garlic (Allium sativum) on the side effects of this medicine has been studied. Materials and Methods:: In this experimental study, the control group did not receive any kind of solvent or medicine, the sham group received solvent; the experimental groups I, II and III received 5 mg/kg of cyclophosphamide and 200, 400, 800 g/kg of hydro alcoholic garlic extracts each day. Fourth experimental group received 5 mg/kg of cyclophosphamide each day and the 5th experimental group received 800 g/kg of hydro alcoholic garlic extracts have been feed to animals and cyclophosphamide is used as injection in peritoneum during the 28 days of experimenting. Results:: The statistical evaluations on the amount of testosterone hormone serum in experimental groups I and IV shows meaningful changes at P ≤ 0.05 in reference to control group, and in experimental groups II and III a meaningful increase in reference to experimental group IV. The amount of FSH hormone also shows a meaningful increase in experimental groups I, II, III and V in reference to control groups and in experimental groups I, II, III, in reference to experimental group IV. The amount of LH hormone also shows a meaningful reduction in experimental group IV in reference to control group and in experimental group IV. Conclusions:: It seems that compounds in the garlic controls the side destructive effects of cyclophosphamide and its metabolites and reduces the side effects of this medicine.