The effect of Hsp90 gene polymorphism on the beef cattle production: a review paper

Abstract

Beef cattle production is a worthwhile worldwide industry that faces many challenges, such as environmental heat stress, which leads to severe economic losses. As part of the heat shock proteins group, Heat Shock Protein 90 (HSP90) is a molecular chaperone common to all eukaryotic cells. It helps to protect cells from damage caused by heat shock. Reviewing polymorphisms of the HSP90 gene and their relationship with beef production was the purpose of this article. We described the structure of the HSP90 and its functions on living cells during adaptation to stress conditions. We also evaluated the HSP90 gene expression role and its polymorphisms on heat stress reaction in livestock. In conclusion, all livestock, especially cattle, are sensitive to heat stress depending on the amount of polymorphism in the hsp90 gene. Under heat stress conditions, HSP 90 and its polymorphism increase cell survivability and regulate body temperature.