Abstract
The effect of different histone preparations on early embryonic development of the sea urchin Strongylocentrotus dröbachiensis has been studied. Different preparations of histones proved to produce similar effects: they do not affect the earliest stages of development until the stage of middle blastula. Development stops at different stages, beginning from blastula just before hatching, depending on the time and duration of the action as well in histone concentration and histone type. The effect of histones is not connected with their polycationic nature, but is determined by their specific structure. It is suggested that the histones may act on the morphogenetic function of the nucleus, possibly, on the synthesis of RNAs which are necessary for accomplishing certain stages of development. This suggestion finds its support in the fact that the character of the effect produced by histones is like that of such typically “nuclear” factors as actinomycin D, some nucleotide analogs and radiation.
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