Abstract
Objective: to assess the effect of viruses of herpes family in pregnant women on the health of children in the first half of their lives.A clinical and laboratory observation of 33 mother-child pairs was conducted. Of these, 25 women were from the risk group for intrauterine infection and 8 women were with a physiological course of pregnancy. The quantitative content of herpes virus markers was studied by their effect on cholesterol metabolism and symbiotic microbiota was studied by the quantitative content of long chain fatty acids and fatty aldehydes, phospholipids by gas chromatography-mass spectrometry in all women at 34-37 weeks of gestation and their infants.It was revealed that pregnant women of “risk group” increased the quantitative content of herpes virus markers with the prevalence of herpes simplex virus (HSV) 1,2 types and its associations with cytomegalovirus (CMV) and Epstein-Barr virus (EBV).A correlation was found between the degree of increase in markers of HSV, EBV, and CMV with that of the bacterial load of the intestine by conditionally pathogenic representatives and the deficiency of priority genera of the intestinal microbiota in mothers and the same indicators in their children.An increase in the quantitative content of herpes viruses, exceeding the norm by more than 2 times, is interconnected with the pathological course of pregnancy and the violation of the microecological status of pregnant women, which predicts the realization of somatic and infectious pathology in children in the first half of life.
Highlights
Цель: оценить влияние вирусов семейства герпес у беременных женщин на состояние здоровья их детей в первое полугодие жизни
The quantitative content of herpes virus markers was studied by their effect on cholesterol metabolism and symbiotic microbiota was studied by the quantitative content of long chain fatty acids and fatty aldehydes, phospholipids by gas chromatography-mass spectrometry in all women at 34-37 weeks of gestation and their infants
It was revealed that pregnant women of “risk group” increased the quantitative content of herpes virus markers with the prevalence of herpes simplex virus (HSV) 1,2 types and its associations with cytomegalovirus (CMV) and Epstein-Barr virus (EBV)
Summary
ФГБОУ ВО Оренбургский государственный медицинский университет Минздрава России, г. Цель: оценить влияние вирусов семейства герпес у беременных женщин на состояние здоровья их детей в первое полугодие жизни. Превышающее норму более, чем в 2 раза, взаимосвязано с патологическим течением беременности и нарушением микроэкологического статуса беременных женщин, что прогнозирует реализацию соматической и инфекционной патологии у детей в первое полугодие жизни. An increase in the quantitative content of herpes viruses, exceeding the norm by more than 2 times, is interconnected with the pathological course of pregnancy and the violation of the microecological status of pregnant women, which predicts the realization of somatic and infectious pathology in children in the first half of life. Нарушение формирования состава микробиоты в антенатальном периоде, её количественных и качественных параметров сопряжено с нарушением её метаболических, защитных и структурных функций, что приводит к развитию патологических состояний, триггерно или непосредственно связанных с активацией условно-патогенных микроорганизмов дисбиотической микробиоты и во многом определяет состояние здоровья ребёнка в первое полугодие жизни [1]. Цель исследования — изучить влияние герпесвирусов на формирование здоровья детей и выявить микроэкологические предикторы, влияющие на данный процесс у детей первого полугодия жизни
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