Abstract
The activity of bilirubin UDPglucuronyltransferase is low in the livers of newborn mice. Within a week after birth the activity of the enzyme rises to the adult level in mice which are dwarfs because of a deficiency of growth hormone and a partial deficiency of thyroid stimulating hormone, but surpasses the adult value by about 60% in normal mice. Neither growth hormone nor thyroxine is effective in elevating enzyme activity in the dwarfs. Within two weeks after birth the activity of the enzyme in normal mice declines to that in the dwarfs. At maturity a marked decrease in bilirubin UDPglucuronyltransferase activity occurs in normal males. Testosterone appears to be responsible for this decrease.
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