Abstract
The present study was conducted to elucidate the antioxidant capacity of green tea (Camellia sinensis) extract against Tamoxifen citrate-induced liver injury. Four groups containing ten female Wister rats each were selected: Group I, served as control group, Group II, permitted Green Tea Extract (1.5% w/v in water) as the sole drinking fluid, Group III, injured by intraperitoneal injection of Tamoxefin (45 mg/ Kg/day) for 7 successive days and Group IV, permitted green tea extract as a sole source of drinking water (1.5% w/v in water) 4 days prior and 14 days after Tamxifen-intoxication (45 mg/Kg/day for 7 successive days). Hepatic oxidative damage was observed in Tamoxefin treated rats as evidenced via augmentation in liver lipid peroxidation as well as depletion in liver antioxidant enzymes; catalase, superoxide dismutase and glutathione peroxidase with highly degeneration and necrosis of the hepatocytes. Histopathological studies of liver treated with Tamoxefin revealed that supplementation of green tea extract resulted in mild degeneration and necrosis of the hepatocytes. Furthermore, green tea extract had normalized catalase, superoxide dismutase, glutathione peroxidase and liver lipid peroxidation content. In Conclusion, the supplementation of green tea extract appeared to be beneficial to a great extent in attenuating and restoring the damage sustained by Tamoxefin exposure.
Highlights
Interest has increased in naturally-occurring antioxidants that can be used to protect human beings from oxidative stress damage [1] because natural antioxidant from plants is generally recognized as safe in the form of extract
They formed of polyhedral hepatocytes which are radically arranged in anatomizing and branching plates separated by vascular blood sinusoids (Figures 1 and 2)
The results in this study indicated that TAM inhibited superoxide dismutase (SOD), CAT and glutathione peroxidase (GPX) activities in liver of rat where decrease in antioxidant defenses in the liver was due to liver damage [27]
Summary
Interest has increased in naturally-occurring antioxidants that can be used to protect human beings from oxidative stress damage [1] because natural antioxidant from plants (e.g. green tea) is generally recognized as safe in the form of extract. Green tea polyphenols and epigallocatechin-3-gallate (EGCG) have potent chemo preventive and therapeutic effect against numerous cancers of skin, lung, breast, colon, liver, stomach and prostate [2]. P-glycoprotein activity, which is responsible for the chemotherapy drugs resistance could be overcome green tea polyphenols [3]. Green tea catechins was reported to modulate cell signaling pathways associated with angiogenesis, metastasis and invasion including the inhibition of vascular endothelial growth factor as well as the inhibition of matrix metallo-proteinases [4]. Anticipate that the combination of green tea catechins and anticancer drugs will be an effective strategy to enhance the therapeutic effects and reduce the adverse effects of anticancer drugs in cancer patients [7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
