The Effect of Gene Mutations on Metastasis and Overall Survival in Metastatic and Nonmetastatic Colon Cancers.

Murat Cag,Neslihan Basgoz,Emel Colak,Mevlude Inanc,Dilek Kaan,Nuriye Coskun,Hakan Sarici,Yusuf Ozkul,Yesim Ozdemir,Muhammet Dogan,Kemal Deniz

doi:10.31557/apjcp.2021.22.12.3839

Murat Cag, Neslihan Basgoz + Show 9 more

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https://doi.org/10.31557/apjcp.2021.22.12.3839

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Abstract

Objective:It is known that many genes are associated with colon cancer. We aimed to investigate the effect of gene mutations on metastasis and overall survival in metastatic and non metastatic colon cancers. Methods:A total of 50 patients with metastatic (n=25) and non metastatic (n=25) diagnosed with colon cancer between 2010 and 2018 were included in the study. APC, MUTYH, RAD50, MEN1, ATM, PALB2, NSH2, BRCA1, BRCA2, MLH1, BRIP1, TP53, PTEN, BARD1, MSH6, PMS2, NBN, and FAM175A gene mutations were evaluated using the next generation sequencing method. The effect of gene mutations on metastasis and overall survival were evaluated. Results:The mean age of patients with colon cancer without distant metastasis was 48.64±14.72 years and for patients with distance metases was 56.68±11.65. The mean survival time of colon cancer patients with distant organ metastasis after the metastasis date was 104.36±58.59 weeks. The presence of APC, MUTYH, and TP53 genetic mutations was observed with a higher rate in metastatic colon cancer (p<0.05). Conclusion:We showed that APC, MUTYH, and TP53 mutations are associated with distant organ metastasis.

Highlights

Colorectal cancer (CRC), with more than 1.8 million new cases diagnosed in 2018, is one of the most common cancers worldwide (Schrembs et al, 2018)
We showed that adenomatous polyposis coli (APC), MUTYH, and TP53 mutations are associated with distant organ metastasis
Identifying individual risk factors for the development of CRC and even risk factors causing local or distant metastasis and recurrence is very important as it can provide prognostic information for clinicians (Xu et al, 2020) CRC was one of the first tumors in which the various genes and pathways involved in the development and progression of the disease were investigated in detail (Fear on et al, 2011; Vogelstein et al, 1988;Vogelstein et al, 2013) From a genomic perspective, it is assumed that colorectal cancer is not a single disease, but a heterogeneous group of malignancies occurring in the colon

Summary

Introduction

Colorectal cancer (CRC), with more than 1.8 million new cases diagnosed in 2018, is one of the most common cancers worldwide (Schrembs et al, 2018). Identifying individual risk factors for the development of CRC and even risk factors causing local or distant metastasis and recurrence is very important as it can provide prognostic information for clinicians (Xu et al, 2020) CRC was one of the first tumors in which the various genes and pathways involved in the development and progression of the disease were investigated in detail (Fear on et al, 2011; Vogelstein et al, 1988;Vogelstein et al, 2013) From a genomic perspective, it is assumed that colorectal cancer is not a single disease, but a heterogeneous group of malignancies occurring in the colon. Critical pathways include APC, TP53, KRAS, NRAS, BRAF, BRCA1/2, BMPR1A, Her, PIK3CA, transforming growth factor (TFG)-β, and mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2 (Pearlman et al, 2016)

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