The Effect of Ganoderma Lucidum Powder on some Immune Parameters in Rat

Abstract

The impact of Ganoderma lucidum powder on both chemokines, IgG and C3 complement concentrations, as well as WBC types, was investigated in 60 ester citrine rats split between two groups, one of which was injected with Carbon tetrachloride CcL4 and the other with Ganoderma lucidum powder. They were not given this drug; instead, two concentrations of mushroom powder, 40 mg/ per kilo-gram of body weight and 80 mg/ per kilo gram of body weight, were utilized, along with a control group. The results revealed a clear increase in all immune factors measured, with a clear difference between males and females when compared to control samples, as well as an increase in the numbers of both neutrophils and lymphocytes in males for both concentrations, with a higher increase for the second concentration than the first, while the increase in females for both concentrations was similar. In the groups exposed to CcL4, an increase in the values of chemokines, IgG, and C3 as well as the number of neutrophils appeared in males in varying numbers for both concentrations, whereas the increase in females appeared in the second concentration higher than the first concentration of immune values, and the opposite was true for the number of white cells. The number of monocytes showed slight changes in both males and females under study with clear significant differences between C3, chemokine, white blood cell count, lymphocytes and monocytes.