Abstract
BackgroundAcute pancreatitis is a life-threatening necroinflammatory disease that is characterized by systemic inflammatory response syndrome and acute lung injury even in its very first days. Erythropoietin (EPO) is a hormone considered as an antiapoptotic and cytoprotective with observed receptors of anti-inflammatory effect on organs apart from the liver and the kidneys. In this study, the effects of EPO on pulmonary mast cells and on secondary injury caused by acute pancreatitis are investigated.MethodsTwenty one Wistar Albino rats were divided into three groups—sham, control, and EPO groups—with 7 rats per group. Pancreatitis was induced by administering 4.5% sodium taurocholate into the pancreatic duct. A 1000 U/kg/day dosage (three times) of EPO was administered to the EPO group. Blood urea nitrogen (BUN), creatinine, amylase, and troponin I in the serum were studied; and lung, kidney, brain, and heart tissues were examined histopathologically.ResultsThere were no histopathological changes in the other organ tissues except for the lung tissue. Compared to the control group, the EPO group showed significantly reduced alveolar hemorrhage, septal neutrophil infiltration, lung wall thickness score, and mast cell count in the lung tissue.ConclusionsAdministration of EPO reduces the mast cell count and lung wall thickness, and it reduces the alveolar hemorrhage and septal infiltration induced by acute pancreatitis.
Highlights
Acute pancreatitis is a life-threatening necroinflammatory disease that is characterized by systemic inflammatory response syndrome and acute lung injury even in its very first days
The intergroup analyses showed no significant variations for amylase, Blood urea nitrogen (BUN), and troponin I values but a statistically significant difference for the creatinine value (p = 0.001) was
Binary comparisons showed that the difference in creatinine value was due to the Control (Median ∓ standard error (SE): 0,3 ∓ 01) and the EPO groups (Median ∓ SE: 0,2 ∓ 0,005) (p = 0.001)
Summary
Acute pancreatitis is a life-threatening necroinflammatory disease that is characterized by systemic inflammatory response syndrome and acute lung injury even in its very first days. Erythropoietin (EPO) is a hormone considered as an antiapoptotic and cytoprotective with observed receptors of anti-inflammatory effect on organs apart from the liver and the kidneys. The effects of EPO on pulmonary mast cells and on secondary injury caused by acute pancreatitis are investigated. Acute pancreatitis (AP) is a life-threatening necroinflammatory disease. Systemic inflammatory response syndrome (SIRS) that develops during the course of the disease and owing to multiple organ failure (MOF) is a major cause of morbidity and mortality. The disease confines itself to a single organ 80% of the time; with the development of MOF, it is related to mortality by 40% [2,3]. Supporting therapies have been developed for the treatment of pancreatitis, definite treatments capable of reducing the severeness of the inflammation do not yet exist [4].
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