The effect of erythropoietin on endometrial edema during ischemia–reperfusion injury in rats

Abstract

Aim:The aim of this experimental study was to examine the effect of erythropoietin (Epo) on rat model and particularly in an ischemia–reperfusion protocol. The beneficial effect or non-effectiveness of that molecule was studied pathologically using endometrial edema (EE) lesions.Materials and methods:Forty rats of mean weight 247·7 g were used in the study. Endometrial edema was evaluated 60 minutes after reperfusion (groups A and C) and 120 minutes after reperfusion (groups B and D) with administration of the drug Epo in groups C and D.Results:Keeping the Epo administration non-significantly increased the EE scores by 0·0333333 [−0·622554–0·6892207] (P = 0·9186). This finding was in accordance with the results of Wilcoxon signed-rank test (P = 0·9089). Keeping reperfusion time non-significantly increased the EE by 0·0666667 [−0·5889466–0·7222799] (P = 0·8380), also in accordance with Wilcoxon signed-rank test (P = 0·5079). However, keeping Epo administration and reperfusion time together non-significantl...