The effect of erythropoietin on platelet distribution width during ischemia reperfusion injury in rats

Abstract

OBJECTIVE: Aim of this experiment study was the erythropoietin (Epo) testing, on rat model and particularly on ischemia reperfusion protocol. The benefit or the non effect of that molecule was studied hematologically on platelet distribution width (PDW). MATERIAL and METHODS: 40 rats were used of mean weight 247,7 gr. PDW was measured at these time points: on 60 min after reperfusion (groups A and C), and on 120 min after reperfusion (groups B and D), A and B without but C and D with Epo administration. RESULTS: Epo administration increased significantly the PDW levels by 0.22 % [0.034374 % - 0.4056259 %] (P= 0.0214), in accordance also with paired t-test (P= 0.0196). Reperfusion time decreased significantly the PDW levels by 0.27 % [0.4483669 % - 0.0916332 %] (P= 0.0040), in accordance also with paired t-test (P= 0.0012). Interaction of Epo administration and reperfusion time increased non significantly the PDW levels by 0.06 % [-0.054648 % - 0.1819207 %] (P= 0.0615). CONCLUSION: Epo administration has significant increasing short-term effects on PDW levels. However, reperfusion time attenuates significantly this effect. Their interaction seems to resemble the action of Epo administration. The following question is whether these PDW levels alterations are the cause or the result of diseases process modification.