The Effect of Dutasteride and Tomato Extract Combination on Reducing Blood Loss after Transurethral Resection of the Prostate

Abstract

Context: Lycopene, a carotenoid found in tomatoes, possesses antiangiogenic activities that might be useful in the management of prostate enlargement. However, the current evidence is still inconclusive in regard to this matter. Aims: The aim of the study was to investigate the effect of combined oral dutasteride and lycopene consumption in reducing posttransurethral resection of the prostate (TURP) bleeding. Settings and Design: Twenty-two individuals diagnosed with benign prostatic hyperplasia were randomly allocated into two groups of equal size. Thirty days prior to TURP, individuals in Group 1 (control) were given daily oral dutasteride 0.5 mg and placebo pill and individuals in Group 2 (intervention) were given dutasteride 0.5 mg and lycopene 30 mg. Subjects and Methods: The parameters measured in this study were pre- and post-TURP plasma erythrocyte count and microvessel density (MVD) of resected prostate tissue stained with CD34. Statistical Analysis Used: Data homogeneity was tested using the Shapiro–Wilk test. Individuals' characteristics were analyzed using the Mann–Whitney U-test and plasma erythrocyte and MVD analyzed using the t-test. Spearman's correlation analysis was performed to find significant correlations between the two variables. Results: There were two dropouts. The mean MVD in the control group was significantly higher compared to the intervention group (28.2 ± 12.3 vs. 18.3 ± 7.6 vessel/mm2, P = 0.044). Reduction of post-TURP plasma erythrocytes was significantly higher in the control group compared to the intervention group (−0.34 ± 0.18 vs. −0.17 ± 0.12 106/μL, P = 0.048). Conclusions: Daily consumption of dutasteride and lycopene for at least 30 days reduced the formation of blood vessels in the prostate and reduced blood loss post-TURP.