The Effect of Dosing with Lemon Juice on the Renal Tissue of Laboratory Rats with Kidney Stones (Urolithiasis/ Nephrolithiasis) Experimentally

Abstract

Kidney stones and renal tissue damage are common diseases that are affected by many causes, including nutritional causes. There have been many ways to treat kidney disease and ways to prevent it through appropriate diets. The research aimed to study the effectiveness of lemon juice in preventing kidney disease in laboratory rats. As 15 animals were distributed in three groups, the first was considered a control group that was dosed with distilled water and the other group was dosed with ethylene glycol as a cause of kidney injury, while lemon juice was used to treat the latter. It was found through the histological sections of the kidneys that the lemon extract helped to preserve the kidneys of the animals, as the glomeruli appeared regularly with the integrity of the epithelial cells of the renal tubules. It was found that the rates of damage to the renal glomeruli in the group treated with lemon did not differ significantly from the animals that were not exposed to infection (the control group). And the damage rate is about 22%. The percentage of damage to the glomeruli in the histological sections of animals that were dosed with the causative agent of stone formation (ethylene glycol) and not treated was about 75%, as the results of histological cutting indicated that they contained atrophy in the renal glomeruli with dissection of Bowman’s capsule and hemorrhage on the surface with calcium crystals deposits.