Abstract
SummaryThe effect of diuretics on the distribution of sodium (Na) and potassium (K) in the kidney was studied in alcohol anaesthetized rats during osmotic diuresis. As previously reported, these rats had a small gradient from cortex to papilla in the sodium concentration of renal tissue. Vasopressin increased this gradient by increasing the concentration of sodium in the medulla and papilla.When either mercaptomerin or hydrochlorothiazide was administered in therapeutic doses, the concentrations of sodium in the papilla were initially high and were further increased by vasopressin. These results were very similar to those obtained when infusions containing high levels of sodium chloride (NaCl) were administered to normal rats.Prior administration of ethacrynic acid caused very high concentrations of sodium in the papilla which were not significantly increased after vasopressin. Ethacrynie acid did not prevent the conscious rat from producing a concentrated urine when deprived of water.This suggests that these drugs do not exert their diuretic effect by decreasing the extra tubular osmotic pressure around the collecting ducts.
Published Version
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