Abstract
Abstract The effect of direct injection of chelating agents into simulated puncture wounds contaminated with 239Pu nitrate has been investigated. The ability to stimulate absorption of 239Pu from the injection site decreases in the order: Desferrioxamine (DFOA) > calcium diethylenetriaminepentaacetate (DTPA) ≫ disodium dipicolinate > trisodium citrate. Substantially better results are obtained by simultaneous administration of mixtures of DTPA + dipicolinate, DTPA + DFOA, DFOA + citrate, and DTPA + citrate, all showing virtually the same effectiveness. The retention pattern of 239Pu translocated from the wound into body organs after chelation therapy is considered as a measure of the complex stability in vivo. Greatest reduction in the skeleton and liver is achieved by DTPA and by its combination with DFOA or citrate. On the other hand, the 239Pu transferred from the injection site shows increased proportional deposition in the kidneys by DFOA, in the skeleton by dipicolinate and in the liver and skeleton by citrate. Combinations of DTPA with tartrate, lactate, pyruvate or chinolinate as well as those of citrate with dipicolinate or chinolinate are equally or less effective than DTPA or DFOA alone. Hyaluronidase does not influence the effectiveness of treatment. Up to about 90% of 239Pu can be removed from the injection site by treatment 1 hr after administration and up to about 30% 3 weeks later. Practical implications of these findings are discussed.
Published Version
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