Abstract
This research aimed to investigate the effect of administering water fraction of Clinacanthus nutans [Burm.F.] Lindau (the local name of daun dandang gendis) in different doses on hypoglycemia. The research method was using the test of dandang gendis leaves (Clinacanthus nutans (Burm.f.) Lindau) water fraction on wistar rats using pre and post test method randomized control group design. The induction using a high-fat diet consisting of pork oil: duck egg (3:1) and fructose 1.8 g/kgBW for 30 days was applied. Rats were divided into 6 groups: normal control (aquadest), negative control (carboxyl methyl cellulose/CMC), positive control (metformin), dose I 15,89 mg/kgBW (water fraction of Clinacanthus nutans [Burm.F.] Lindau), dose II 31,78 mg / kgBW, and dose III 47,67 mg / kgBW. The result showed that a dose of 15,89 mg/kg BW was an effective dose to reduce blood glucose level. of wistar male rats induced by fructose and high-fat feed.
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