The Effect of Cinnamon Bark Extract (Cinnamomum burmanii) on Blood Malondialdehyde (MDA) Levels in Hyperglycemia Rats

Abstract

Hyperglycemia is a condition where blood glucose levels increase beyond normal limits. Hyperglycemia can induce oxidative stress conditions caused by an increase in free radicals and a reduction in endogenous antioxidant defenses, characterized by an increase in blood malondialdehyde levels. Oxidative stress causes malondialdehyde levels to increase and endogenous antioxidants to decrease, therefore the body needs exogenous antioxidants. One plant that is rich in antioxidants is cinnamon bark, where cinnamon bark can increase antioxidant capacity. This study aims to examine the effect of cinnamon bark extract (Cinnamomum burmanii) on reducing blood malondialdehyde levels in hyperglycemic rats. This research is experimental research using the Post Test-Only Control Group design. Male Wistar rats were divided into 5 groups (n=6), negative control (K-), positive control (K+), P1 (dose 100 mg/kgBW), P2 (dose 200 mg/kgBW), P3 (dose 300 mg/kgBW). The normality test was carried out using the Shapiro-Wilk test followed by One Way Anova and Kruskal Wallis. The results showed that cinnamon bark (Cinnamomum burmanii) was proven to be able to reduce blood malondialdehyde levels, where the optimal dose was P1 (dose 100mg/kgBW) whereas in the P1 group, the average malondialdehyde levels were found to be the lowest compared to other treatment groups. Keywords: Hyperglycemia; cinnamon bark; malondialdehyde; oxidative stress