Abstract
Post-stroke cognitive impairment involves memory, visuoconstructional, and
 spatial dysfunctions. Centella asiatica L. Urban. and Curcuma longa L. are both
 well-known herbs in South and South-East Asia countries that are believed to
 possess neuroprotective properties as memory enhancers. This study aimed to
 investigate the effects of C. asiatica L. Urban. and C. longa L. extracts combination
 in improving memory performance in stroke model rats and its acute toxicity.
 Twenty-five Wistar rats underwent transient bilateral common carotid artery
 occlusion. Y-maze pre-test was performed 24 h after the occlusion. The rats were
 then divided into five groups i.e. Group 1 received NaCMC dilution, Group 2
 received donepezil 0. 7 mg/kg BW/day, and Groups 3, 4, and 5 received the extracts
 combination with dose of 59; 118; and 236 mg/kg BW/day, respectively. Y-maze
 post-test was performed 24 h after the last dose had been given. Spontaneous
 alternation behavior was used as the indicator of working memory measurement.
 The fixed-dose method according to OECD Guideline was used to estimate the
 LD50 in acute toxicity testing on Wistar rats. There was a significant difference
 in the delta spontaneous alternation percentage among groups tested (p<0. 05).
 Group 1 had significant difference with any other group (compared to Groups
 2 to 5; p<0.05). No significant difference could be found between groups of the
 extracts combination and donepezil group suggesting that the effect is not more
 inferior nor dose-dependent in improving memory performance. The extracts
 combination at a single dose of 2000 mg/kg BW did not show related signs of
 toxicity or mortality in any of the rats during the 14-day observation period. In
 conclusion, the C. asiatica L. Urban. and C. longa L. extracts combination can
 improve performance of memory on stroke model animal. According to Globally
 Harmonized Classification System, the extracts combination can be classified as
 Category 5/unclassified.
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