The Effect of Celery Ethanol Extract on Proteinuria in Unilateral Ureter Obstruction Rat Model

Abstract

Chronic kidney disease (CKD) is a condition of decreased kidney function that occurs for more than three months. Proteinuria is one of the markers of impaired kidney function, especially in the renal filtration process. Unilateral ureter obstruction causes impaired kidney function, including the filtration process. Celery (Apium graveolens L.) contains phenolic compounds that can prevent the decrease of kidney function. This study aims to determine the effect of celery ethanol extract on proteinuria in the UUO rat model. This study was an experimental study with a post-test only with control group design. A total of 25 rats were assigned to 5 groups. Group 1: sham control, 2: negative control (UUO), 3: UUO with 125 mg/kgBW celery ethanol extract, 4: UUO with 250 mg/kgBW celery ethanol extract, and 5: UUO with 500 mg/kgBW celery ethanol extract. The treatment of celery ethanol extract was given for 14 days. Urine samples were taken on the 15th day for examination of proteinuria. The results were analyzed by the Oneway ANOVA test and showed a significant difference between the control group and the treatment groups (p<0.05). A dose of 250mg/kgBW is the most effective dose of celery ethanol extract in this study.