The effect of carbofuran administration on protoplasmic astrocyte cell necrosis in the cerebrum of mice (Mus musculus)

Abstract

The aim of this study was to investigate the exposure of the insecticide carbofuran on the necrosis of protoplasmic astrocyte cells in the cerebrum of mice (Mus musculus). Twenty mice were divided into four groups with five replicates each. The control group (P0) received 0.5% physiological NaCl, P1 (carbofuran 0.0833 mg/kg BW), P2 (carbofuran 0.0417 mg/kg BW), P3 (carbofuran 0.0208 mg/kg BW), and carbofuran was administered for ten days. On the 12th day, brain necropsy and HE staining were performed to observe the necrosis of protoplasmic astrocyte cells in the mice cerebrum. The necrosis of protoplasmic astrocyte cells was analyzed using ANOVA followed by Duncan's test. The results showed that carbofuran caused necrosis of protoplasmic astrocyte cells (p < 0.05), and the necrosis increased with increasing carbofuran dosage (p < 0.05).