The effect of carbetocin on the mammary gland of pigs

Abstract

Carbetocin (deamino-1-monocarba-(2-Omethylthyrosine)-oxytocin) refers to a prolonged-acting, synthetic analogue of oxytocin, has pharmacodynamic properties similar to natural oxytocin. Drugs containing carbetocin have been used in the pathology of childbirth and the postpartum period. However, there is limited information in the literature on the effect of this pharmacological agent on the mammary gland of animals. The aim of the presented experimental work was to study the effect of carbetocin on the mammary gland of sows in the postpartum period. The studies were performed on the main sows in the early postpartum period. According to the principle of analogues, the animals were divided into 2 groups: experimental and control. Carbetocin was parenterally administered to sows of the experimental group at a dose of 0.07 mg with an interval of 24 hours, and uterotonic agents were not used in the control group. In animals of the experimental group, the time of induced secretion of breast secretions after administration of cabetocin was recorded. The concentration of immunoglobulins in colostrum (milk) of all studied animals was determined using a Brix refractometer. It was found that after carbetocin injection, the average duration of excretion of mammary gland secretions in sows had no significant differences during 1 and 2 days after delivery and amounted to 363.00±8.40 and 355.50±8.51 minutes, respectively. Its free release in animals occurs within 4-7 hours after administration of a prolonged oxytocin analog. The use of carbetocin in sows in the postpartum period does not lead to an increase in the amount of immunoglobulins in colostrum or transitional milk, regardless of the proportion of the mammary gland. At the same time, a significant decrease in immune proteins is recorded after 24 hours to the initial level.