Abstract
Objective: This study aims to prove the effect of supplementation of bitter melon leaves extract on glycemic status in diabetic foot ulcer (DFU).
 Materials and Methods: This study used a randomized, double-blinded, and placebo-controlled trial. Thirty DFU patients based on PEDIS 1-8 scores who met the criteria were divided into 2 groups consisting of 15 patients as a treatment group with the administration of bitter melon leaves extract at a dose of 6 g/day and 15 patients as a control group of with placebo. This intervention was conducted in 4 weeks. Glycemic status was measured by the value of glycated albumin and examined at baseline and at the end of treatment. Data were analyzed using paired t-test and independent t-test.
 Results: After 4 weeks of treatment, there was an increase in the baseline value of glycated albumin in the treatment group from 24.5 ± 11.7% to 25.8 ± 12.7% or an increase of 1.3 ± 6.3% and a decrease in the control group from 27.5 ± 13.1% to 25.8 ± 8.5% or a decrease of 1.7 ± 12.4%. The results of the analysis of the effect of supplementation of bitter melon leaves extract on the value of glycated albumin were not significant (p = 0.99).
 Conclusion: The supplementation of bitter melon leaf extract with a dose of 6 g / day did not significantly affect the value of glycated albumin.
 Bangladesh Journal of Medical Science Vol.20(2) 2021 p.281-287
Highlights
Diabetes mellitus (DM) has increased the prevalence in the world, especially in developing countries[1,2]
The aim of this study is to prove the effect of Bitter melon leaves extract on glycemic status in the diabetic foot ulcer (DFU)
PatientsThe inclusion patient’s criteria were diabetic foot ulcer patients with PEDISscores met of 1-8, aged 30-65 years old, hemoglobin levels of > 10 g/dl, Body Mass Index (BMI) of 18.5 - 22.9, albumin levels of > 3 g / dl, ankle-brachial value index (ABI)> 0.6 - 1.3, Length of DM: 0-15 years, willing to participate in this research and consider to sign the informed consent
Summary
Diabetes mellitus (DM) has increased the prevalence in the world, especially in developing countries[1,2]. The Effect of Bitter Melon (Momordica charantia L.) Leaves Extractonon Glycated Albumin in Diabetic Foot Ulcers: Randomized Controlled Trial than those without DM6-7.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
