Abstract
Wistar rats were fed chow supplemented with 1% (w/w) aspirin for one month. At 3, 7, 14, 21 and 30 days of treatment, heparinized blood was collected. ATP, Na+, K+ levels, glucose utilization of erythrocytes and inorganic phosphate, Na+, K+, salicylate levels of plasma were determined. Erythrocyte ATP and plasma phosphate levels were decreased following aspirin treatment. ATP decrement caused erythrocyte K+ level to diminish significantly. Plasma Na+ and K+ levels were not effected by aspirin treatment. In addition, the decrease in ATP levels induced erythrocyte glucose utilization. It was concluded that the therapeutic dose of aspirin in man, gave rise to a decrease in the energy production and an impairment of energy utilizing events in erythrocytes in rats (the therapeutic serum aspirin concentration in man is 25-40 mg dL−1).
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