Abstract
Objective: To give a visualization and explanation whether the use of ARV during exclusivebreastfeedingperiod is able to reduce the rate of transmission during exclusive breastfeeding.Methods: Systematic review of cross-sectional studies, case control, cohort studies, and prospectivestudies using Pubmed, LWW Journals, and Science Direct for literature search. Literature publishedbetween 2010 and 2020 are researched. Results are recorded using PRISMA, MMAT is used for biasriskevaluation.Results: A total of 2090 breastfed infants were included among the 2 studies. The first journal includedwas by Coovadiaet al.2012 was a 3rd phase clinical regarding the use of extended NVP on HIV exposedinfants were exclusive breastfed, concluded that the transmission rate for the group that receivedextendedNVP was only 1.1%. Rutagweraet al. 2019, focused on the shedding of HIV virus into thebreastmilk which is why this study used breastmilk as their sample4,6. Rutagweraet al. 2019. foundalmost 80% of their subjects shed HIV virus into their breastmilk6. This number is correlated to thetransmission of HIV vertically in breastfeeding mother.Conclusion: To conclude, the use of ARV does affect the rate of transmission of HIV from mother tochild during breastfeeding.
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