The effect of aqueous extract of Cinnamonum zeylanicum on some biochemical parameters in male white rats in which rheumatoid arthritis is induced

Abstract

The current study was designed to investigate the effect of Cinnamonum zeylanicum (Cz) aqueous extract in reducing the effect of rheumatoid arthritis (RA) in white male rats induced by complete Freund's adjuvant (CFA), Twenty five male white rats were used, Weights range (200 – 320) grams and ages (11-14) weeks, and Each group contains five Rats, The first group G1 returned the negative control group that was given normal saline solution, the second group G2 was injected with a dose of 0.1 ml with CFA in the right plantar foot to induce rheumatoid arthritis. On the first day of the experiment, positive control was returned for groups G5, G4, and G3, a dose of 250, 350, 450 mg/kg of (Cz) aqueous extract of body weight after 14 days of induction of arthritis, respectively, for 20 days. Blood samples were collected from animal groups. All from the last day of the experiment to measure the following parameters malondialdehyde( MAD), glutathione (GSH), and catalase (CAT), The results showed that arthritis induction led to a significant increase (p <0.05) in the MAD concentration level, compared with the G1 group., and the treatment of individuals of groups G5, G4, G3 with aqueous Cz extract led to a significant decrease (p <0.05) in the MAD concentration level,. The concentration level of both GSH and CAT decreased significantly (p <0.05). In the individuals of Group G2 compared with G1, then returns to a significant increase (p <0.05) in groups G3, G4, and G5, as the concentrations reached ( compared with the positive control group G2, and from it, we conclude that arthritis induction by CFA leads to a significant increase (p <0.05) in the MAD concentration level in the serum of individuals of animals, as well as a significant decrease (p <0.05) in the concentration of both GSH and CAT, respectively, and treatment with different concentrations of Cz aqueous extract reduced joint inflammation by restoring the levels of the above parameters to a level close to normal.