Abstract
The current study aimed to evaluate the anti-arthritic effects of a nanocomposite from Cinnamomum zeylanicum, and to further demonstrate its mechanism of action in RA induced RA by Complete Freund's Adjuvant (CFA). and it was diagnosed by atomic force microscopy (AFM) and infrared spectroscopy (FT-IR) revealed the emergence of new diffraction levels for nanocomposites, which clearly indicates the success of the loading process. X-ray evaluation clearly showed the severity of joint deformity according to the extent of osteoarthritis, joint spaces, soft tissue inflammation, subchondral erosion, and articular sclerosis. The immunological results indicated that the induction of rheumatoid arthritis (RF) in male G2 white rats led to a significant (P<0.05) increase in the level of IL-1β and IL-6 cytokines (186.89,109.52) pg/ml both compared with the control group. Negative (G1) (29.40,32.48) pg/ml. There was also a significant decrease (P<0.05) for the concentration level of IL-1β, IL-6 in the G7 group dosed with cinnamon nano compound loaded with MTX pg/ml (34.33, 48.62), respectively, the present results indicate that the stable nanoparticles with Ceylon Cinnamomum extract (Z.C./NPs) have potent anti-arthritic activity that is mediated by IL-6, IL-1β inhibition and cytokine resistance. Inflammatory.
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