Abstract
Hypertension is a chronic medical condition in which blood pressure in the arteries is elevated. This research work studied the effect of antihypertensive drugs specifically beta adrenergic blockers (atenolol) and angiotensin converting enzymes (lisinopril) on tears secretion and stability in adults. A total of 75 people (35 65years) male and female participated and completed the study with a mean age of 52.8±1.83years. These subjects were divided into group A (control) comprised of 25 normotensive subjects; group B (experimental) which comprised of 25 hypertensive subjects on atenolol alone (beta blocker) and group C (experimental) comprised of 25 hypertensive subjects on lisinopril (angiotensin converting enzymes ) alone .Tear volume was determined using schirmer strips and tear stability was determined using fluroscein strip. These patients were examined for all the tests at first week (baseline) and repetition of all tests one week later after oral drug administration of atenolol (Group B) or lisinopril (Group C). When the tear break up at time baseline and follow up measurement of group B were compared, it was observed that there was a statistically significant decrease (P<0.05). When the tear breakup time at baseline and follow up measurements of Group C were compared, it was observed that there was a statistically significant decreased.(P<0.05) The use of antihypertensive drugs atenolol (beta blocker) has an effect on the tear break up time. Also lisinopril (angiotensin converting enzyme inhibitor) has an effect on tear break time.
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